Substances in nature mostly consist of one form of the enantiomer. When a natural substance is artificially synthesized,
the racemate is produced, which has both a left-hand type and right-hand type
on a fifty-fifty basis. In this case,
the problem is that when this artificial synthetic substance activates in vivo,
another type is ineffective or shows a completely different effect, while one
type shows a desired function.
Therefore, in the case of the drug with enantiomer, the FDA in 1992,
requires all the data to be submitted on the toxicity of each single isomer so
as to actively encourage development of a new drug as a single isomer with optical
activity, which is a very effective medicine and has low side-effects.
In accordance with the determination of the policy by the FDA in the
U.S.A., the number of chiral drugs sold as a single isomer has rapidly
increased as of late. In a case in 1993,
more than 50% of 1,850 kinds of natural and synthesized drugs sold on the
market were chiral drugs, of which more than 50% were sold as a single isomer. Moreover, 17 out of the top 25 (70%) drugs
sold in 1994 were those with optical activity, which occupy about 70% of the
total items.
For this reason, pharmaceutical companies throughout the world are focusing
on the research to isolate and purify isomers that have an effect on medicine,
and replacing existing racemic drugs with chiral drugs. Therefore, the marketability and importance
of chiral drugs are being gradually increased.
However, highly advanced technology must be required to isolate these isomers
or to synthesize only one isomer because all the enantiomers have the same
chemical structural formula and physicochemical properties such as melting and
boiling points and solubility.
Enzytech Co., Ltd. is developing new technology to isolate or synthesize the
chiral building block (chiral synthon), which will be the raw material of the chiral
drug. Based on the technologies
successfully developed to date, we started our business and we are making our
best effort to become one of the worlds leading suppliers for chiral building
blocks and pharmaceutical raw materials for chiral.
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